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KMID : 0043319990220060579
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Archives of Pharmacal Research
1999 Volume.22 No. 6 p.579 ~ p.584
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Synthesis and In Vitro Antibacterial Activity of Quaternary Ammonium Cephalosporin Derivatives Bearing Oxazolidinone Moiety
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Chung In-Hwa
Kim Choong-Sup
Seo Jae-Hong
Chung Bong-Young
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Abstract
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Several oxazolidinones having amine moiety were prepared to form a quaternay ammonium salt with cephalosporin nucleus, and antibacterial activity of the quaternary ammonium cephalosporin derivatives bearing oxazolidinone moiety were examined particularly with expectation of dual activity. However, the cephalosporin-oxazolidinone compounds revealed rather weaker antibacterial activity in vitro than their parent oxazolidinone and cephalosporin without showing any characteristic activity as expected.
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KEYWORD
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Oxazoidinone, Quaternary ammonium cephalosporin, Antibacterial activity
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